Horvath Epigenetic Age
82.4 yr
DNA Damage Foci (γ-H2AX)
14.8 foci/cell
hTERT Expression Level
0.12 (Suppressed)
p16_INK4a Expression
13.2 relative
SASP IL-6 Concentration
11.4 pg/mL
SASP TNF-alpha
9.8 pg/mL
Telomere Length
4.8 kbp
NAD+ Pool
11.2 pmol/mg
Epigenetic AgeAccel
+4.4 yr
p21_Cip1 Expression
2.1 relative
CpG site methylation density vector (Horvath Clock Sites):
cg022256470.85
cg018203740.42
cg197263540.73
cg034458920.61
cg062214840.39
cg084473610.90
process ZOMBIE_CELL_CLEARANCE(
senescent_fraction: Decimal,
therapy: REJUVENATION_THERAPY
) -> Decimal {
let ic50_d = Decimal::new(26, 3); // 26nM
let ic50_q = Decimal::new(78, 1); // 7.8uM
// Hill pd synergy model
let e_d = therapy.dasatinib_conc /
(therapy.dasatinib_conc + ic50_d);
let e_q = therapy.quercetin_conc /
(therapy.quercetin_conc + ic50_q);
// Bliss Independence
let total_eff = 1.0 - (1.0 - e_d)*(1.0 - e_q);
return senescent_fraction * (1.0 - total_eff);
}